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Alert About Ozempic and Mounjaro: Necessary Precautions to Avoid Muscle Mass Loss During Treatment.
Medications like Ozempic and Mounjaro, popular in the treatment of obesity, can lead to muscle mass loss. Experts warn of the need for strength exercises and adequate protein intake to minimize this side effect.
The fight against obesity, a global problem affecting over a billion people, has gained new allies with the arrival of medications like Ozempic (semaglutide) and Mounjaro (tirzepatide).
These medicines, which reduce appetite and promote weight loss, have proven effective in treating obesity, which affects 56% of adults in Brazil, but they also raise concerns about muscle mass loss.
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Recent studies indicate that while these medications promote significant weight loss, they can also lead to a considerable decrease in lean mass, which includes muscles, organs, bones, and fluids.
Muscle mass loss not only affects strength and quality of life but is also associated with an increased risk of mortality.
The Importance of Medical and Nutritional Monitoring Without Ozempic
Experts emphasize the importance of medical and nutritional monitoring during the use of these medications.
Proper protein intake and regular strength training are crucial to minimize muscle mass loss and ensure that weight loss is sustainable in the long term.
“It’s not enough to just consume protein and take whey protein without engaging in physical activity,” warns endocrinologist Maria Edna de Melo. “It’s necessary to do strength exercises, like weightlifting, to build muscles.”
The protein requirement during treatment with these medications is about 1.5 grams per kilogram of body weight.
Additionally, strength training two to three times a week can reduce lean mass loss from 35% to 20%.
The Risks of Improper Use of Ozempic
The recreational or aesthetic use of these medications, without appropriate medical and nutritional guidance, can have catastrophic results. Excessive muscle mass loss can lead to malnutrition and other serious health issues.
“We have seen many cases of people using these medications without medical supervision, adhering to restrictive diets, and not exercising,” warns physician Cynthia Valério. “The impact on body composition can be devastating.”
Benefits Beyond Weight Loss
Despite the risks, the benefits of these medications in treating obesity are undeniable. Significant weight loss can lead to improvements in metabolic health, such as a reduced risk of type 2 diabetes and cardiovascular diseases.
Furthermore, studies show that weight loss with these medications can lead to improved muscle quality, even if there is a reduction in the total amount of muscle mass.
A New Horizon in Obesity Treatment
Obesity is a complex and multifactorial health issue, with genetic, social, cultural, economic, and environmental causes.
The arrival of new medications like Ozempic and Mounjaro represents a significant advancement in the treatment of this disease. However, it is essential that the use of these medications is closely monitored by healthcare professionals to ensure that the benefits outweigh the risks.
According to Novo Nordisk, semaglutide has been subjected to robust clinical studies involving thousands of patients, demonstrating a reduction effect on lean mass and fat, but with a greater emphasis on reducing body fat. Consequently, an increase in the total proportion of lean body mass was observed.
The combination of medications, balanced diet, and physical exercise continues to be the best strategy for obesity treatment. Novo Nordisk recommends that patients using semaglutide follow medical guidelines, eat healthily, and engage in physical activities to ensure that weight loss occurs as safely as possible.
Novo Nordisk A/S. Semaglutide PSUR/PBRER July 18, 2023, version 1.0. Data on file.
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