Coffee Can Interfere With The Action Of Medications Such As Antidepressants, Asthma Medications, And Thyroid, Increasing Side Effects Or Reducing Effectiveness
For many people, the day only starts after a cup of coffee. The drink is popular, energizing, and part of the daily routine. But what few know is that this combination can be risky for those taking certain medications. Coffee can interfere with the action of common drugs and even increase side effects.
Cold And Asthma Medications
Caffeine is a stimulant. When consumed together with decongestants like pseudoephedrine, found in cold medications, the effects can add up. This means a higher risk of insomnia, headaches, increased heart rate, and nervousness.
Some cold medications already contain caffeine. When a person takes these medications and still drinks coffee, the caffeine dose rises. There are studies indicating increased blood sugar and body temperature with this mixture—something that can concern people with diabetes.
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Other medications that require attention are those used for ADHD, such as amphetamines, and those for asthma, such as theophylline. They are all stimulants. When combined with coffee, they can cause effects such as increased heart rate and difficulties sleeping.
Interference With The Thyroid And Bones
Those treating hypothyroidism with levothyroxine should be cautious about when they drink coffee. Taking the beverage right after the pill can reduce the medication’s absorption by up to 50%. This happens because caffeine speeds up the digestive system and disrupts the absorption time of the medication.
Furthermore, caffeine can bind to the medication in the stomach and prevent it from entering the bloodstream properly. This is especially true for the pill form. If absorption decreases, symptoms of hypothyroidism may return: fatigue, weight gain, and constipation.
The same caution applies to osteoporosis medications, such as alendronate and risedronate. The recommendation is to take them on an empty stomach and wait 30 to 60 minutes before eating or drinking anything, including coffee.
Antidepressants And Antipsychotics
The relationship between coffee and mental health medications is more complex. Selective serotonin reuptake inhibitors (SSRIs), such as sertraline and citalopram, may have their absorption reduced if taken with caffeine. This can diminish the treatment’s effect.
Tricyclic antidepressants, such as amitriptyline and imipramine, are processed by the same liver enzyme that metabolizes caffeine.
This generates competition that can keep the medication in the body longer, increasing the risk of side effects. At the same time, caffeine may also take longer to be eliminated, which leads to agitation for a longer period.
The situation becomes even more delicate with clozapine, an antipsychotic also metabolized by the same enzyme. One study showed that two or three cups of coffee could nearly double the amount of clozapine in the bloodstream. This raises the risk of drowsiness, confusion, and even more severe problems.
Coffee And Pain Relievers
Some pain relievers, such as those containing aspirin or acetaminophen, already include caffeine in their formula. Drinking coffee alongside can speed up the absorption of these medications, as the beverage stimulates stomach emptying.
This causes the effect to hit faster. However, it may also increase the risks of heartburn, irritation, and even stomach bleeding, especially if other sources of caffeine are consumed. Even without severe cases reported, the warning is to use with moderation.
Heart Medications
Caffeine can raise blood pressure and quicken heartbeats for up to four hours. In people taking medications to control blood pressure or heart rhythm, this can diminish the effect of the drugs.
This doesn’t mean that those with heart problems need to cut coffee entirely. But it is important to observe how the body reacts. If symptoms worsen, it may be necessary to reduce consumption or opt for decaffeinated coffee.
The way the body reacts to coffee varies from person to person. While some tolerate several cups a day well, others feel strong effects from just one.
Therefore, if there is any doubt about using medications with coffee, it is best to consult a doctor or pharmacist. Combining the two without guidance can impair treatment and pose unnecessary risks.
With information from O Antagonista.

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