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Science With a Brazilian Accent: UFRJ’s Polylaminin Restores Movement and Could Become a Global Milestone in the Fight Against Paralysis

Written by Caio Aviz
Published on 11/09/2025 at 22:22
Mão de paciente em cadeira de rodas simboliza avanço da polilaminina no combate à paralisia
Paciente em cadeira de rodas representa a esperança trazida pela polilaminina no tratamento de lesões medulares
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Protein Derived from Human Placenta Restores Movement to Patients and Already Shows Results in Humans and Animals

An unprecedented scientific breakthrough has emerged in Brazil and has captured the attention of the international medical community.

In 2015, researchers applied poly-L-lysine for the first time in humans, a protein derived from the human placenta. This compound stimulates neuron regeneration and reverses paralysis. The Federal University of Rio de Janeiro (UFRJ) developed the study in partnership with the Cristália laboratory. The medication showed positive results in both patients and animals.

Thus, the discovery became a landmark unprecedented in modern medicine, as the reversal of damage to the spinal cord had been considered impossible until then.

Discovery Driven by Brazilian Science

The poly-L-lysine has been continuously studied under the leadership of researcher Tatiana Coelho de Sampaio, a professor at UFRJ.

According to experts, the protein acts directly on the spinal cord. In addition, it stimulates neuronal rejuvenation and the formation of axons, fibers that transmit electrical impulses throughout the body.

Therefore, the compound established itself as the most promising path to restore movement to paralyzed individuals, contrary to previous medical predictions.

YouTube Video

Patient Recovering After Severe Accident

One of the most remarkable cases occurred in 2015, when Bruno Drummond de Freitas, 31, suffered an accident that left him tetraplegic.

He received the poly-L-lysine application 24 hours after the trauma. In an interview with Folha de S.Paulo, he reported: “In about five months, I was completely recovered. I have a normal routine, I play sports, and I no longer undergo any type of treatment”.

Furthermore, in a statement to G1, he added: “Nowadays, I can move around completely, of course with certain limitations… I can lift, walk, dance, fly. This has ensured my independence”.

The result surprised specialists and opened doors for new clinical protocols.

Animal Tests Confirm Potential

In addition to studies in humans, poly-L-lysine was tested on rodents and dogs with severe spinal cord injuries.

In 2021, six tetraplegic dogs received the medication. As a result, four of them regained significant movement, went back to walking, and showed significant improvement in quality of life.

These advances were subsequently published in international scientific journals, further reinforcing the significance of the discovery and expanding its global impact.

Medical and Social Impacts of the Discovery

The development of poly-L-lysine opens perspectives for a revolution in neurological treatments. According to specialists, the Brazilian medication has the potential to transform the lives of thousands of people around the world.

Besides physical recovery, the achieved results restored to patients independence, self-esteem, and dignity, fundamental factors for social reintegration.

However, scholars warn that the advancement requires stringent protocols, expanded clinical trials, and ethical regulations to ensure safety and efficacy on a large scale.

Path to New Applications

Based on the results already achieved, expectations are growing that poly-L-lysine will enter into multicenter clinical trials and international testing.

According to medical specialists, cooperation between universities, research centers, and the pharmaceutical industry will be essential to expand the therapy’s reach and consolidate its application in the treatment of spinal injuries.

Moreover, the fact that the development took place in Brazil reinforces the importance of national science in generating innovative solutions with global impact.

The Discovery in an International Context

The creation of poly-L-lysine accompanies other medical advances that are transforming neuroscience.

While many treatments remain restricted to laboratories, the Brazilian medication stands out for showing concrete results in humans in a relatively short period.

Thus, poly-L-lysine has solidified its position as a relevant discovery on a global scale, as clinical evidence has been published in highly credible outlets.

What Does the Future Hold for Medicine?

Experts believe that poly-L-lysine could change the course of global neurology, ushering in a new era of regenerative treatments.

However, the challenge is to ensure broad access, responsible regulation, and rigorous scientific monitoring so that the discovery becomes a lasting solution.

The medication, a result of research in Brazilian public universities, confirms that national science can be at the forefront of major medical revolutions.

And you, do you believe this breakthrough will definitively transform the treatment of spinal injuries worldwide?

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Caio Aviz

Escrevo sobre o mercado offshore, petróleo e gás, vagas de emprego, energias renováveis, mineração, economia, inovação e curiosidades, tecnologia, geopolítica, governo, entre outros temas. Buscando sempre atualizações diárias e assuntos relevantes, exponho um conteúdo rico, considerável e significativo. Para sugestões de pauta e feedbacks, faça contato no e-mail: avizzcaio12@gmail.com.

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