Omeprazol pode aumentar risco de demência em 33%

Long-Term Use Of Omeprazole May Cause Dementia, Study Warns

Written by Caio Aviz

Published on 02/06/2025 at 20:18

Updated on 02/06/2025 at 20:19

Representação simbólica do uso de medicamentos no cuidado da saúde cerebral e funções cognitivas

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Study Reveals That Prolonged Use of Omeprazole and Similar Drugs May Significantly Affect Cognitive Health

Popular medications in Brazil, such as omeprazole, pantoprazole, and esomeprazole, belonging to the class of proton pump inhibitors (PPIs), are now under rigorous scrutiny by the medical community. According to a study published in August 2023 in the journal Neurology, these drugs, when used continuously for more than four years, may increase the risk of dementia by up to 33%. The study was conducted by researchers from the University of Minnesota in the United States and followed 5,712 adults with an average age of 75 for about 4.4 years.

Daily Medications Require Constant Medical Attention

Although effective against reflux, gastritis, and ulcers, PPIs may cause side effects when used for extended periods, according to recent studies. In Brazil, omeprazole is widely sold and recommended, but new warnings highlight the risks of prolonged use without adequate medical supervision. For Kamakshi Lakshminarayan, a physician and co-author of the research, the correlation observed, although with no proven causality, already requires attention from doctors and patients.

History of Studies Reinforces Warnings About Prolonged Use

This is not the first time that PPIs have been linked to potential health complications. Previous research has already associated these medications with kidney problems, vitamin B12 deficiencies, and even bone fractures in the elderly. However, this new study is one of the first to present a significant link between continuous use and the loss of cognitive functions. The data showed that among participants who did not use PPIs, the incidence of dementia was lower compared to those who used them regularly for more than four years.

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Self-Medication Increases Risks and Requires Professional Guidance

In addition to being easily accessible in Brazilian pharmacies, many patients resort to PPIs without medical recommendation. This behavior, coupled with the lack of periodic monitoring, significantly contributes to the risks described in the study. Physicians emphasize the importance of using these medications only when prescribed and with constant reevaluations. When necessary, therapeutic alternatives should be considered, especially for elderly individuals, who are naturally more prone to neurological conditions.

Health Professionals Should Reassess Clinical Practices

Based on the latest scientific evidence, experts have encouraged the medical sector to review protocols and avoid unrestricted use of PPIs in prolonged treatments. In addition, healthcare institutions are already discussing new approaches for gastroesophageal reflux, prioritizing less invasive methods with a lower neurological impact. This debate intensifies with an aging population, necessitating preventive policies focused on protecting cognitive functions.

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Long-Term Use Of Omeprazole May Cause Dementia, Study Warns

Study Reveals That Prolonged Use of Omeprazole and Similar Drugs May Significantly Affect Cognitive Health

Daily Medications Require Constant Medical Attention

History of Studies Reinforces Warnings About Prolonged Use

Self-Medication Increases Risks and Requires Professional Guidance

Health Professionals Should Reassess Clinical Practices

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Long-Term Use Of Omeprazole May Cause Dementia, Study Warns

Study Reveals That Prolonged Use of Omeprazole and Similar Drugs May Significantly Affect Cognitive Health

Daily Medications Require Constant Medical Attention

History of Studies Reinforces Warnings About Prolonged Use

Self-Medication Increases Risks and Requires Professional Guidance

Health Professionals Should Reassess Clinical Practices

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Workers were opening a modern road in Dover when they found, 6 meters below the asphalt, a 3,500-year-old boat made of stitched oak and plant fibers.

Dissatisfied with seeing people sleeping on the street, a man named Ryan Donais started building small mobile homes so that homeless people can escape the cold, each equipped with a bed, running water, electricity, and heating.

Consumers eat six times more chicken than in the 1960s, global meat supply quadruples in 60 years, and FAO report reveals the invisible cost on the plate: livestock could drive 80% of the increase in agricultural emissions over the next decade.

An Indonesian fisherman pulls a mysterious object from the sea and discovers that it is a Chinese underwater monitoring system, part of the so-called Underwater Great Wall that Beijing uses to track submarines and unmanned vehicles in strategic straits of the region.

Two 17-year-old Kenyans use coconut shells, corn cobs, and recycled materials to create an exhaust filter that reduces 93.3% of pollutant particles and wins an environmental award in Africa.

Man built a 5-acre lake to raise bass, but after 1,000 days the project turned into a wildlife sanctuary with eagles, deer, ducks, owls, and live cameras that transformed the farm into a biodiversity laboratory.

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Weg is the Brazilian company most exposed to Trump’s tariff hike. The multinational manufacturer of industrial motors and equipment, headquartered in Jaraguá do Sul (SC), is racing against time to reduce the impact of the new U.S. taxation.