Advances In Medicine: U.S. Authorizes Pig Kidney Transplant Trials In Humans Using eGenesis Technology

Written by Sara Aquino

Published on 09/09/2025 at 09:26

Fonte: IA

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Pig Kidney Transplant in Humans Gets the Green Light in the US. Discover How eGenesis Can Transform Global Public Health.

Revolution in Public Health: Pig Kidney Transplants in Humans Receive Green Light in the US

The United States authorized on Monday (8) a historic step for public health: the start of clinical trials for pig kidney transplants in humans.

The initiative will be led by the biotechnology company eGenesis, which develops genetically modified animals to provide organs compatible with the human body. The decision came from the Food and Drug Administration (FDA), the US regulatory agency responsible for drugs and food.

Thus, the goal is to address one of the biggest crises in modern medicine: the shortage of available organs for transplantation. Currently, more than 100,000 people in the US are waiting for an organ, with 86% needing a kidney.

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How EGenesis Technology Works

In this scenario, eGenesis relies on genetic engineering to enable this milestone. Their pigs undergo DNA alterations with the CRISPR technique, which allows for “editing” specific genes. The focus is to inactivate the gene responsible for producing the carbohydrate alpha-gal, a substance that causes almost immediate rejection when a pig organ is transplanted into humans.

Therefore, with this modification, the pigs’ kidneys become more compatible, drastically reducing the risks of rejection.

“The technique represents an unprecedented advancement in the field of transplants”

Highlighted specialists cited by CNN.

Experimental Cases Already Conducted in the US

Although the formal authorization was only announced now, experiments with organ transplants from animals, known as xenotransplants, were already underway.

On June 14, doctors at Massachusetts General Hospital performed the third experimental pig kidney transplant in humans.

The patient, identified as Bill Stewart, surprised doctors with his rapid recovery. After the surgery, he returned home and, in no time, went back to his work activities.

This result reinforced the scientific community’s confidence that biotechnology can save thousands of lives.

History of Xenotransplants and Next Steps

The first major xenotransplant experiment took place in 2022, when the University of Maryland School of Medicine performed a pig heart transplant on a terminal patient.

At the time, the procedure was authorized only under emergency rules. Now, with the official FDA approval, the tests gain clinical and scientific scale.

In this way, experts believe that if the results remain positive, pig kidney transplants could become a viable alternative to reduce long waiting lists.

Moreover, the advancements represent a concrete hope for people in at-risk situations who cannot find compatible donors in time.

Impact on Global Public Health

The green light from the US for the tests is not only a breakthrough for the country but also a win for global science. The possibility of producing organs in the laboratory from genetically modified animals could completely transform the landscape of public health.

Thus, the expectation is that, in the medium term, xenotransplants will help balance the demand for organs and reduce the mortality of patients who are currently waiting for years on waiting lists.

Therefore, if the efficacy and safety of the procedure are confirmed, the world may witness a true medical revolution led by eGenesis.

Advances In Medicine: U.S. Authorizes Pig Kidney Transplant Trials In Humans Using eGenesis Technology

Pig Kidney Transplant in Humans Gets the Green Light in the US. Discover How eGenesis Can Transform Global Public Health.

Revolution in Public Health: Pig Kidney Transplants in Humans Receive Green Light in the US

How EGenesis Technology Works

Experimental Cases Already Conducted in the US

History of Xenotransplants and Next Steps

Impact on Global Public Health

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Advances In Medicine: U.S. Authorizes Pig Kidney Transplant Trials In Humans Using eGenesis Technology

Pig Kidney Transplant in Humans Gets the Green Light in the US. Discover How eGenesis Can Transform Global Public Health.

Revolution in Public Health: Pig Kidney Transplants in Humans Receive Green Light in the US

How EGenesis Technology Works

Experimental Cases Already Conducted in the US

History of Xenotransplants and Next Steps

Impact on Global Public Health

The Soviet Union spent 22 years drilling into the Earth’s crust and reached a depth of 12,262 meters — they found water where it was thought impossible, hydrogen bubbling from the rock, granite that is 2.7 billion years old, and temperatures of 180 degrees that melted the drill bits.

Norway is drilling 27 kilometers of rock 392 meters below the bottom of a fjord to build the world’s largest and deepest underwater road tunnel — when completed, a 21-hour journey will be reduced to 10.

Chinese engineers begin filling a 217-meter dam at an altitude of 3,000 meters and prepare a 2,240 MW hydroelectric power plant to integrate hydropower, solar, and wind energy in the upper Jinsha.

A German architect built a cylindrical house in 1994 that rotates to follow the sun throughout the day, generates 5 times more energy than it consumes, and was the world’s first energy-positive house.

An astronaut spent 340 days in space while his twin brother stayed on Earth, and NASA found a “rejuvenating” effect, genes, microbiome, cognition, and immune system that revealed the biological cost of living outside the planet.

China has just successfully tested the world’s first ground effect maritime vehicle, a craft that flies up to 6 meters above the water at 200 km/h, uses quantum technology and 6G communication, and can rescue patients in the middle of the ocean.

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